Portugal began life after Cristiano Ronaldo with a 4-1 defeat to Denmark in Braga.
The loss saw them miss the opportunity to secure the top spot in UEFA Nations League Group A4.
Pierre-Emile Hojbjerg gave Denmark the lead with a penalty just before half-time.
Rasmus Hojlund then netted a brace in the space of eight minutes after the break.
Joachim Andersen headed in the fourth goal with 15 minutes left, before Bernardo Silva’s consolation in added time.
Ronaldo called time on his international career last week after a record 234 appearances and 146 goals.
UNL: Portugal thrashed 4-1 by Denmark in first game after Ronaldo's retirement